LAM-AI Case: 23-3200-Abdel-Latif-ACC

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23-3200-Abdel-Latif-ACC

Necropsy pathology case report for IVAC Service ID 23-3200.

LAM-AI Case ID: STUDY_23_3200

IVAC Service ID: 23-3200

Necropsy Date: 12/4/23

Species: ACC

Principal Investigator: Abdel-Latif

Case Type: necropsy pathology case

Case Focus: veterinary diagnostic pathology

Reference Source: IVAC pathology report

Overview

Study

Provider: IVAC pathology report
Case Information: STUDY_23_3200 — necropsy pathology case
Goal: veterinary diagnostic pathology
Title: 23-3200-Abdel-Latif-ACC

Subject

1 animal Species: ACC ID: SUBJ_23X10878

2.5-month-old (DOB 9/13/23) male spiny mouse found deceased on 12/4/23. No previous history.

Samples

10 tissue/sample records

Adrenal Glands, All Tissues, Brain, Gastrointestinal tract, Heart, Kidneys, Liver, Lungs and 2 more

Sample records link to corresponding gross and microscopic findings where a reliable relationship is available.

Assays / Findings

Report

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Final Diagnosis / Conclusion

Final Diagnoses

Organ/System	Process	Diagnosis
Whole Body		Diffuse marked autolysis of all body systems
Gastrointestinal	Infectious	Endoparasitism - see comments

Final Comments / Conclusion

The high degree of post-mortem autolysis severely limits gross and histological interpretation. Sections of the gastrointestinal tract contain increased numbers of protozoa organisms. It is likely that what is being observed is an overgrowth of commensal organisms following death. To more accurately rule-out true endoparasitism within the colony, fresh fecal samples collected from several animals to submit for fecal floatation (ova/parasite) screening.

Clinical History

Clinical History Narrative

2.5-month-old (DOB 9/13/23) male spiny mouse found deceased on 12/4/23. No previous history.

Animal / Subject Profile (1)

Animal ID	Clinical Number	Species	Age	Sex	Genotype / Strain	Mode of Death
23x10878		ACC	2.5 months	M	N/A	Found Deceased

Interventions / Treatments

No intervention or treatment records are linked to this case.

Recorded Conditions / Events (3)

Condition / Event	Severity	Timing	Subject	Details
Marked autolysis	marked	necropsy date	SUBJ_23X10878	Organ/System: Whole body; Process: ; Morphologic Diagnosis: Marked autolysis
Diffuse marked autolysis of all body systems	Not specified	necropsy date	SUBJ_23X10878	Organ/System: Whole Body; Process: ; Diagnosis: Diffuse marked autolysis of all body systems
Endoparasitism - see comments	Not specified	necropsy date	SUBJ_23X10878	Organ/System: Gastrointestinal; Process: Infectious; Diagnosis: Endoparasitism - see comments

Final diagnoses and microscopic morphologic diagnoses are summarized separately at the bottom of Overview and in the pathology findings tabs.

Samples

Tissues / Samples (10)

Tissue / Organ	Sample Type	Collection	Subject
Adrenal Glands SAMP_23_3200_ADRENAL_GLANDS	histology slide/tissue	necropsy 2023-12-04 T0: necropsy date	SUBJ_23X10878
All Tissues SAMP_23_3200_ALL_TISSUES	histology slide/tissue	necropsy 2023-12-04 T0: necropsy date	SUBJ_23X10878
Brain SAMP_23_3200_BRAIN	histology slide/tissue	necropsy 2023-12-04 T0: necropsy date	SUBJ_23X10878
Gastrointestinal tract SAMP_23_3200_GASTROINTESTINAL_TRACT	histology slide/tissue	necropsy 2023-12-04 T0: necropsy date	SUBJ_23X10878
Heart SAMP_23_3200_HEART	histology slide/tissue	necropsy 2023-12-04 T0: necropsy date	SUBJ_23X10878
Kidneys SAMP_23_3200_KIDNEYS	histology slide/tissue	necropsy 2023-12-04 T0: necropsy date	SUBJ_23X10878
Liver SAMP_23_3200_LIVER	histology slide/tissue	necropsy 2023-12-04 T0: necropsy date	SUBJ_23X10878
Lungs SAMP_23_3200_LUNGS	histology slide/tissue	necropsy 2023-12-04 T0: necropsy date	SUBJ_23X10878
Spleen SAMP_23_3200_SPLEEN	histology slide/tissue	necropsy 2023-12-04 T0: necropsy date	SUBJ_23X10878
Whole body SAMP_23_3200_WHOLE_BODY	histology slide/tissue	necropsy 2023-12-04 T0: necropsy date	SUBJ_23X10878

Microscopic and additional-assay links use direct sample relationships. Gross links use a controlled tissue-to-organ-system mapping and are only shown when a confident mapping is available.

Gross Findings

Finding present Evaluated, no finding Not evaluated / unavailable

Organ System	Evaluated? (Y/N/Some animals)	Findings Y/N	Comments
Cardiovascular	Y	N
Endocrine	Y	N
Gastrointestinal	Y	Y	Severe gaseous distension of abdomen, stomach, and cecum--suspect postmortem change.
Hematolymphoid	Y	N
Hepatic	Y	N
Integument	Y	N	The skin has a green hue and the hair easily sloughs -> Consistent with marked autolysis.
Musculoskeletal	Y	N
Nervous	Y	N
Reproductive	Y	N
Respiratory	Y	N
Special senses	Y	N
Urinary	Y	N

Microscopic Findings

Finding present Examined, no finding Not evaluated / unavailable

Organ / Slide	Findings Y/N	Description
Adrenal Glands	N; NO MICROSCOPIC FINDINGS REPORTED.
All Tissues	Y	All tissues examined are markedly autolytic greatly inhibiting the ability to evaluate organ structure and identify potential lesions. Large basophilic bacilli (cadaver bacilli) are present in several tissues, area common finding in cases with severe autolysis, and are not associated with disease.
Brain	N; NO MICROSCOPIC FINDINGS REPORTED.
Gastrointestinal tract	Y	Within the lumen of the GI tract, commonly associated with ingesta, are myriads of unicellular protozoa organisms. Some are approximately 15-20um in length, have a tear dropped body shape, and an occasionally apparent flagella. Others are 50-60um in diameter, round, and ciliated. Several poorly staining oblong objects, approximately 15-20um in length, with flattened apices (bi-opperculated?) are seen admixed with the ingesta. These objects may be consistent with parasite ova. See comments
Heart	N; NO MICROSCOPIC FINDINGS REPORTED.
Kidneys	N; NO MICROSCOPIC FINDINGS REPORTED.
Liver	N; NO MICROSCOPIC FINDINGS REPORTED.
Lungs	N; NO MICROSCOPIC FINDINGS REPORTED.
Spleen	N; NO MICROSCOPIC FINDINGS REPORTED.

Microscopic Morphologic Diagnoses

Organ / System	Process	Morphologic Diagnosis
Whole body		Marked autolysis

Documentation

Document	Type	Provider / Creator	File / Reference	Status
IVAC pathology report 23-3200	necropsy pathology report	Benjamin Curtis, DVM, DACVP Final Review Pathologist	Master 2023 Necropsy Log.xlsx::23-3200-Abdel-Latif-ACC Source file reference only; direct public download is not available in VaxSEA. IVAC pathology report: 23-3200	Complete: Yes 2023-12-21

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