ULAM IN-VIVO ANIMAL CORE
UNIVERSITY OF MICHIGAN
Main Laboratory
North Campus Research Complex
2800 Plymouth Rd., Bld. 36: G155/157
Ann Arbor, MI 48109-2800
(734) 647-0731
North Campus Research Complex
2800 Plymouth Rd., Bld. 36: G155/157
Ann Arbor, MI 48109-2800
(734) 647-0731
Satellite Location
3527 Animal Research Facility
1150 W. Medical Center Dr.
Ann Arbor, MI 48109-0614
(734) 936-3803
3527 Animal Research Facility
1150 W. Medical Center Dr.
Ann Arbor, MI 48109-0614
(734) 936-3803
ulam-ivac@umich.edu
Case Information:
| Necropsy Date: | 12/4/23 | Clinician: | Lester |
|---|---|---|---|
| IVAC Service ID: | 23-3200 | Prosector: | Hasler |
| Species: | ACC | Gross necropsy pathologist: | Curtis |
| Principal Investigator: | Abdel-Latif | Other contact: | Suhan |
| Depart: |
Animal ID:
| Animal ID: | Clinical Number: | Age: | Sex: | Genotype/Strain/Study: | Mode of Death: |
|---|---|---|---|---|---|
| 23x10878 | 2.5 months | M | Found Deceased |
Clinical History:
2.5-month-old (DOB 9/13/23) male spiny mouse found deceased on 12/4/23. No previous history.
Final Diagnos(es) for Case
| Organ/System | Process | Diagnosis |
|---|---|---|
| Whole Body | Diffuse marked autolysis of all body systems | |
| Gastrointestinal | Infectious | Endoparasitism - see comments |
Final Comments:
The high degree of post-mortem autolysis severely limits gross and histological interpretation. Sections of the gastrointestinal tract contain increased numbers of protozoa organisms. It is likely that what is being observed is an overgrowth of commensal organisms following death. To more accurately rule-out true endoparasitism within the colony, fresh fecal samples collected from several animals to submit for fecal floatation (ova/parasite) screening.
Pathologist Only:
| Case Complete? | Yes |
|---|---|
| Final Review Pathologist: | Benjamin Curtis, DVM, DACVP |
| Completion Date: | 2023-12-21 |
Gross Findings
| Body condition score: | 3/5 |
|---|---|
| Carcass condition: | Intact |
| Autolysis: | Severe (many organs affected) |
Gross Lesions
| Organ System | Evaluated? (Y/N/Some animals) | Findings or Comments Y/N | Comments (only if Findings) |
|---|---|---|---|
| Cardiovascular | Y | N | |
| Endocrine | Y | N | |
| Gastrointestinal | Y | Y | Severe gaseous distension of abdomen, stomach, and cecum--suspect postmortem change. |
| Hematolymphoid | Y | N | |
| Hepatic | Y | N | |
| Integument | Y | N | The skin has a green hue and the hair easily sloughs -> Consistent with marked autolysis. |
| Musculoskeletal | Y | N | |
| Nervous | Y | N | |
| Reproductive | Y | N | |
| Respiratory | Y | N | |
| Special senses | Y | N | |
| Urinary | Y | N |
Additional Procedures Performed: Check all that apply
| No additional procedures reported. |
Microscopic Findings
| Organ/Slide | Findings Y/N | Description |
|---|---|---|
| Adrenal Glands | N | |
| All Tissues | Y | All tissues examined are markedly autolytic greatly inhibiting the ability to evaluate organ structure and identify potential lesions. Large basophilic bacilli (cadaver bacilli) are present in several tissues, area common finding in cases with severe autolysis, and are not associated with disease. |
| Brain | N | |
| Gastrointestinal tract | Y | Within the lumen of the GI tract, commonly associated with ingesta, are myriads of unicellular protozoa organisms. Some are approximately 15-20um in length, have a tear dropped body shape, and an occasionally apparent flagella. Others are 50-60um in diameter, round, and ciliated. Several poorly staining oblong objects, approximately 15-20um in length, with flattened apices (bi-opperculated?) are seen admixed with the ingesta. These objects may be consistent with parasite ova. See comments |
| Heart | N | |
| Kidneys | N | |
| Liver | N | |
| Lungs | N | |
| Spleen | N |
Microscopic Morphologic Diagnos(es)
| Organ/System | Process | Morphologic Diagnosis |
|---|---|---|
| Whole body | Marked autolysis |