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23-3236-Abdel-Latif-ACC

Necropsy pathology case report for IVAC Service ID 23-3236.

LAM-AI Case ID: STUDY_23_3236

IVAC Service ID: 23-3236

Necropsy Date: 12/14/23

Species: ACC

Principal Investigator: Abdel-Latif

Case Type: necropsy pathology case

Case Focus: veterinary diagnostic pathology

Reference Source: IVAC pathology report

Case Overview

SEA-CDM entity: study analysis

Final pathology diagnosis

SEA-CDM entity: analysis | ANL_23_3236_FINAL_DIAGNOSIS | Reference: 23-3236

Inflammation involving the eyelid and conjunctiva was noted, but there was no clear evidence for any infectious etiology histologically. No neoplasia nor structural anomaly was found. Noninfectious blepharoconjunctivitis was suspected in this case. Such condition has been reported fairly frequently in aging 129 strain of mice, in which age-related structural and functional changes in the lacrimal glands might interfere mucocutaneous barrier function, leading to sterile blepharoconjunctivitis. Co-infection with bacteria is possible, but the bacteria usually were not the primary issue because these bacteria could also be isolated from healthy hosts. SPF housing may not prevent such spontaneous condition.

Case Summary

Case Type	necropsy pathology case
Case Focus	veterinary diagnostic pathology
Description	Necropsy pathology case report for IVAC Service ID 23-3236.
Keywords	ACC; necropsy; histopathology; pathology; Abdel-Latif
Reference Source	IVAC pathology report
Reference ID	N/A

Source Case Metadata

Parsed from study.comments

Source workbook

Master 2023 Necropsy Log.xlsx

Source sheet

23-3236-Abdel-Latif-ACC

Necropsy Date

12/14/23

IVAC Service ID

23-3236

Species

ACC

Principal Investigator

Abdel-Latif

Department

N/A

Case Metadata

SEA-CDM entities: experiment, group

necropsy pathology case

EXP_23_3236 | Reference: 23-3236 | IVAC pathology report

Case Record

Case Record ID	EXP_23_3236
Study / Case ID	STUDY_23_3236
Case Type	necropsy pathology case
Subject Focus	23x10879 Subject ID: SUBJ_23X10879
Source Document	DOC_23_3236

Source Reference

Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC

Reference ID: 23-3236

Reference Source: IVAC pathology report

Clinical History / Case Narrative

Male spiny mouse pup born 11/25/23 presented with its left eye swollen shut on 12/6. Most of the swelling appeared to be underneath the eye. There was also a small skin lesion on the left muzzle. The eye was flushed with sterile saline and treated with neo-poly-bac eye ointment twice (12/6 and 12/8), and the pup received 3 doses of carprofen (12/6, 12/8, and 12/11). The eye did not improve and developed grey crusty discharge, so the pup was euthanized via isoflurane overdose followed by bilateral pneumothorax.

Group / Cohort Summary

Group ID
GRP_23_3236_01
Group key: grp_23_3236_01

Group Type
single animal

Group Size
1

Age Range
2 weeks

Composition

Species

ACC

Sex

Age

2 weeks

Genotype/Strain/Study

N/A

Group Notes

Single-animal pathology case.

SEA-CDM details

Experiment ID	EXP_23_3236
Clean Study Accession	study_23_3236
Clean Experiment Local ID	exp_23_3236
Clean Experiment Accession	exp_23_3236
Group Row Count	1

Animal / Subject

SEA-CDM entity: subject

Subject	Species / Lineage	Sex	Age	Group	Subject Notes
SUBJ_23X10879 Local ID: 23x10879 Animal ID: 23x10879 animal	ACC	M	2 weeks Source: 2 weeks	grp_23_3236_01	Mode of Death: Euthanized-Other Source notes: Animal ID: 23x10879; Clinical Number: ; Age source text: 2 weeks; Mode of Death: Euthanized-Other

Tissues / Samples

SEA-CDM entity: sample

Tissue / Organ	Sample Type	Collection	Subject	Group	Sample ID
Adrenal Glands	histology slide/tissue	necropsy 2023-12-14 T0: necropsy date	SUBJ_23X10879 Key: subj_23x10879	grp_23_3236_01	SAMP_23_3236_ADRENAL_GLANDS Sample key: samp_23_3236_adrenal_glands Reference: 23-3236 Source: IVAC pathology report
Brain	histology slide/tissue	necropsy 2023-12-14 T0: necropsy date	SUBJ_23X10879 Key: subj_23x10879	grp_23_3236_01	SAMP_23_3236_BRAIN Sample key: samp_23_3236_brain Reference: 23-3236 Source: IVAC pathology report
Eye Notes: Microscopic morphologic diagnosis: Blepharoconjunctivitis, focally extensive, subacute, moderate, with orthokeratotic hyperkeratosis	histology slide/tissue	necropsy 2023-12-14 T0: necropsy date	SUBJ_23X10879 Key: subj_23x10879	grp_23_3236_01	SAMP_23_3236_EYE Sample key: samp_23_3236_eye Reference: 23-3236 Source: IVAC pathology report
Heart	histology slide/tissue	necropsy 2023-12-14 T0: necropsy date	SUBJ_23X10879 Key: subj_23x10879	grp_23_3236_01	SAMP_23_3236_HEART Sample key: samp_23_3236_heart Reference: 23-3236 Source: IVAC pathology report
Kidneys	histology slide/tissue	necropsy 2023-12-14 T0: necropsy date	SUBJ_23X10879 Key: subj_23x10879	grp_23_3236_01	SAMP_23_3236_KIDNEYS Sample key: samp_23_3236_kidneys Reference: 23-3236 Source: IVAC pathology report
left eye swab Notes: Culture, left eye swab: Few Streptococcus suis	swab/fluid	necropsy 2023-12-14 T0: necropsy date	SUBJ_23X10879 Key: subj_23x10879	grp_23_3236_01	SAMP_23_3236_LEFT_EYE_SWAB Sample key: samp_23_3236_left_eye_swab Reference: 23-3236 Source: IVAC pathology report
Liver	histology slide/tissue	necropsy 2023-12-14 T0: necropsy date	SUBJ_23X10879 Key: subj_23x10879	grp_23_3236_01	SAMP_23_3236_LIVER Sample key: samp_23_3236_liver Reference: 23-3236 Source: IVAC pathology report
Lungs	histology slide/tissue	necropsy 2023-12-14 T0: necropsy date	SUBJ_23X10879 Key: subj_23x10879	grp_23_3236_01	SAMP_23_3236_LUNGS Sample key: samp_23_3236_lungs Reference: 23-3236 Source: IVAC pathology report
Salivary Glands	histology slide/tissue	necropsy 2023-12-14 T0: necropsy date	SUBJ_23X10879 Key: subj_23x10879	grp_23_3236_01	SAMP_23_3236_SALIVARY_GLANDS Sample key: samp_23_3236_salivary_glands Reference: 23-3236 Source: IVAC pathology report
Skeletal muscle	histology slide/tissue	necropsy 2023-12-14 T0: necropsy date	SUBJ_23X10879 Key: subj_23x10879	grp_23_3236_01	SAMP_23_3236_SKELETAL_MUSCLE Sample key: samp_23_3236_skeletal_muscle Reference: 23-3236 Source: IVAC pathology report
Skull	histology slide/tissue	necropsy 2023-12-14 T0: necropsy date	SUBJ_23X10879 Key: subj_23x10879	grp_23_3236_01	SAMP_23_3236_SKULL Sample key: samp_23_3236_skull Reference: 23-3236 Source: IVAC pathology report
Spleen	histology slide/tissue	necropsy 2023-12-14 T0: necropsy date	SUBJ_23X10879 Key: subj_23x10879	grp_23_3236_01	SAMP_23_3236_SPLEEN Sample key: samp_23_3236_spleen Reference: 23-3236 Source: IVAC pathology report
Sternum	histology slide/tissue	necropsy 2023-12-14 T0: necropsy date	SUBJ_23X10879 Key: subj_23x10879	grp_23_3236_01	SAMP_23_3236_STERNUM Sample key: samp_23_3236_sternum Reference: 23-3236 Source: IVAC pathology report
Stomach and colon	histology slide/tissue	necropsy 2023-12-14 T0: necropsy date	SUBJ_23X10879 Key: subj_23x10879	grp_23_3236_01	SAMP_23_3236_STOMACH_AND_COLON Sample key: samp_23_3236_stomach_and_colon Reference: 23-3236 Source: IVAC pathology report

Treatments / Procedures

SEA-CDM entities: intervention, material

Treatment / Procedure	Type	Route	Timing	Subject / Source	Notes
neo-poly-bac Material ID: MAT_NEO_POLY_BAC Material reference: 23-3252	treatment ID: INT_23_3236_NEO_POLY_BAC	topical	T0: necropsy date	SUBJ_23X10879 Subject key: subj_23x10879 Reference: 23-3236 Source: IVAC pathology report	Male spiny mouse pup born 11/25/23 presented with its left eye swollen shut on 12/6. Most of the swelling appeared to be underneath the eye. There was also a small skin lesion on the left muzzle. The eye was flushed with sterile saline and treated with neo-poly-bac eye ointment twice (12/6 and 12/8), and the pup received 3 doses of carprofen (12/6, 12/8, and 12/11). The eye did not improve and developed grey crusty discharge, so the pup was euthanized via isoflurane overdose followed by bilateral pneumothorax.

Pathology Findings

SEA-CDM entity: occurrence

Finding / Diagnosis	Severity	Timing	Subject / Source	Source Note
Blepharoconjunctivitis, focally extensive, subacute, moderate, ID: OCC_23_3236_BLEPHAROCONJUNCTIVITIS_FOCALLY_EXTENSIVE_SUBACUTE_MODERATE Key: occ_23_3236_blepharoconjunctivitis_focally_extensive_subacute_moderate	moderate	T0: necropsy date	SUBJ_23X10879 Subject key: subj_23x10879 Source: IVAC pathology report	Organ/System: Eye; Process: Inflammatory; Morphologic Diagnosis: Blepharoconjunctivitis, focally extensive, subacute, moderate, with orthokeratotic hyperkeratosis
Blepharoconjunctivitis, sterile ID: OCC_23_3236_BLEPHAROCONJUNCTIVITIS_STERILE Key: occ_23_3236_blepharoconjunctivitis_sterile	N/A	T0: necropsy date	SUBJ_23X10879 Subject key: subj_23x10879 Source: IVAC pathology report	Organ/System: Special senses; Process: Inflammatory; Diagnosis: Blepharoconjunctivitis, sterile

Diagnostic Assays

SEA-CDM entity: assay

Assay	Assay Type	Source / Reference	Linked Results	Assay Notes
Additional Procedures Linked result labels: Additional Procedures	Additional Procedures	No file/source path listed.	2	No assay notes available.
Culture, left eye swab Assay ID: ASSAY_23_3236_CULTURE Assay key: assay_23_3236_culture Linked result labels: Additional Procedures	culture Type key: culture	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC Source file reference only; direct public download is not available in LAM-AI. Source: IVAC pathology report Reference: 23-3236	1	Inferred from Additional Procedures section. Culture, left eye swab: Few Streptococcus suis
Gross necropsy examination Assay ID: ASSAY_23_3236_GROSS Assay key: assay_23_3236_gross Linked result labels: Gross Lesions	gross pathology Type key: gross_pathology	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC Source file reference only; direct public download is not available in LAM-AI. Source: IVAC pathology report Reference: 23-3236	12	Body condition score: 3/5; Carcass condition: Intact; Autolysis: None
Microscopic histopathology Assay ID: ASSAY_23_3236_MICRO Assay key: assay_23_3236_micro Linked result labels: Final Diagnoses; Microscopic Findings; Microscopic Morphologic Diagnoses	histopathology Type key: histopathology	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC Source file reference only; direct public download is not available in LAM-AI. Source: IVAC pathology report Reference: 23-3236	14	No assay notes available.

Results / Observations

SEA-CDM entity: results

29 result/observation record(s) are linked to this case. Records are grouped by report/result section. Routine records with no findings are collapsed by default.

Final Diagnoses (1)

Blepharoconjunctivitis, sterile

Final Diagnoses pathology diagnosis

Process: Inflammatory

Organ/System: Special senses; Process: Inflammatory; Diagnosis: Blepharoconjunctivitis, sterile

Subject: SUBJ_23X10879 Assay: ASSAY_23_3236_MICRO Analysis: ANL_23_3236_FINAL_DIAGNOSIS

SEA-CDM details

Result ID	RES_23_3236_FINAL_DIAGNOSIS_BLEPHAROCONJUNCTIVITIS_STERILE
Original Assay Type	Final Diagnoses
Data Type	pathology diagnosis
Analysis Type	final pathology diagnosis
Group ID	GRP_23_3236_01
Documentation ID	DOC_23_3236
Source Reference	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Related Document	IVAC pathology report 23-3236
Document Reference	IVAC pathology report: 23-3236
Clean Keys	Subject: subj_23x10879 Assay: assay_23_3236_micro

Microscopic Morphologic Diagnoses (1)

Blepharoconjunctivitis, focally extensive, subacute, moderate, with orthokeratotic hyperkeratosis

Microscopic Morphologic Diagnoses pathology diagnosis

Process: Inflammatory

Organ/System: Eye; Process: Inflammatory; Morphologic Diagnosis: Blepharoconjunctivitis, focally extensive, subacute, moderate, with orthokeratotic hyperkeratosis

Subject: SUBJ_23X10879 Sample: SAMP_23_3236_EYE Assay: ASSAY_23_3236_MICRO Analysis: ANL_23_3236_FINAL_DIAGNOSIS

SEA-CDM details

Result ID	RES_23_3236_MORPH_EYE
Original Assay Type	Microscopic Morphologic Diagnoses
Data Type	pathology diagnosis
Analysis Type	morphologic diagnosis
Group ID	GRP_23_3236_01
Documentation ID	DOC_23_3236
Source Reference	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Related Document	IVAC pathology report 23-3236
Document Reference	IVAC pathology report: 23-3236
Clean Keys	Subject: subj_23x10879 Sample: samp_23_3236_eye Assay: assay_23_3236_micro

Microscopic Findings (12)

histopathology observation

Microscopic Findings histopathology observation Findings: Y

Organ/Slide: Skull; Findings: Y; Description: The epidermis of the eyelid is thickened by proliferation of the stratum spinosum and prominent rete ridges (acanthosis), covered by layers of keratin (orthokeratotic hyperkeratosis). The dermis and a lesser extent to epidermis are infiltrated with a small number of lymphocytes and fewer neutrophils. The epithelium of the cornea is slightly disorganized and hyperplastic.

Subject: SUBJ_23X10879 Sample: SAMP_23_3236_SKULL Assay: ASSAY_23_3236_MICRO

SEA-CDM details

Result ID	RES_23_3236_MICRO_SKULL
Original Assay Type	Microscopic Findings
Data Type	histopathology observation
Analysis Type	microscopic observation
Group ID	GRP_23_3236_01
Documentation ID	DOC_23_3236
Source Reference	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Related Document	IVAC pathology report 23-3236
Document Reference	IVAC pathology report: 23-3236
Clean Keys	Subject: subj_23x10879 Sample: samp_23_3236_skull Assay: assay_23_3236_micro

Evaluated with no findings / routine observations (11)

histopathology observation

Microscopic Findings histopathology observation Findings: N

Organ/Slide: Adrenal Glands; Findings: N; No microscopic findings reported.

Subject: SUBJ_23X10879 Sample: SAMP_23_3236_ADRENAL_GLANDS Assay: ASSAY_23_3236_MICRO

SEA-CDM details

Result ID	RES_23_3236_MICRO_ADRENAL_GLANDS
Original Assay Type	Microscopic Findings
Data Type	histopathology observation
Analysis Type	microscopic observation
Group ID	GRP_23_3236_01
Documentation ID	DOC_23_3236
Source Reference	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Related Document	IVAC pathology report 23-3236
Document Reference	IVAC pathology report: 23-3236
Clean Keys	Subject: subj_23x10879 Sample: samp_23_3236_adrenal_glands Assay: assay_23_3236_micro

histopathology observation

Microscopic Findings histopathology observation Findings: N

Organ/Slide: Brain; Findings: N; No microscopic findings reported.

Subject: SUBJ_23X10879 Sample: SAMP_23_3236_BRAIN Assay: ASSAY_23_3236_MICRO

SEA-CDM details

Result ID	RES_23_3236_MICRO_BRAIN
Original Assay Type	Microscopic Findings
Data Type	histopathology observation
Analysis Type	microscopic observation
Group ID	GRP_23_3236_01
Documentation ID	DOC_23_3236
Source Reference	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Related Document	IVAC pathology report 23-3236
Document Reference	IVAC pathology report: 23-3236
Clean Keys	Subject: subj_23x10879 Sample: samp_23_3236_brain Assay: assay_23_3236_micro

histopathology observation

Microscopic Findings histopathology observation Findings: N

Organ/Slide: Heart; Findings: N; No microscopic findings reported.

Subject: SUBJ_23X10879 Sample: SAMP_23_3236_HEART Assay: ASSAY_23_3236_MICRO

SEA-CDM details

Result ID	RES_23_3236_MICRO_HEART
Original Assay Type	Microscopic Findings
Data Type	histopathology observation
Analysis Type	microscopic observation
Group ID	GRP_23_3236_01
Documentation ID	DOC_23_3236
Source Reference	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Related Document	IVAC pathology report 23-3236
Document Reference	IVAC pathology report: 23-3236
Clean Keys	Subject: subj_23x10879 Sample: samp_23_3236_heart Assay: assay_23_3236_micro

histopathology observation

Microscopic Findings histopathology observation Findings: N

Organ/Slide: Kidneys; Findings: N; No microscopic findings reported.

Subject: SUBJ_23X10879 Sample: SAMP_23_3236_KIDNEYS Assay: ASSAY_23_3236_MICRO

SEA-CDM details

Result ID	RES_23_3236_MICRO_KIDNEYS
Original Assay Type	Microscopic Findings
Data Type	histopathology observation
Analysis Type	microscopic observation
Group ID	GRP_23_3236_01
Documentation ID	DOC_23_3236
Source Reference	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Related Document	IVAC pathology report 23-3236
Document Reference	IVAC pathology report: 23-3236
Clean Keys	Subject: subj_23x10879 Sample: samp_23_3236_kidneys Assay: assay_23_3236_micro

histopathology observation

Microscopic Findings histopathology observation Findings: N

Organ/Slide: Liver; Findings: N; No microscopic findings reported.

Subject: SUBJ_23X10879 Sample: SAMP_23_3236_LIVER Assay: ASSAY_23_3236_MICRO

SEA-CDM details

Result ID	RES_23_3236_MICRO_LIVER
Original Assay Type	Microscopic Findings
Data Type	histopathology observation
Analysis Type	microscopic observation
Group ID	GRP_23_3236_01
Documentation ID	DOC_23_3236
Source Reference	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Related Document	IVAC pathology report 23-3236
Document Reference	IVAC pathology report: 23-3236
Clean Keys	Subject: subj_23x10879 Sample: samp_23_3236_liver Assay: assay_23_3236_micro

histopathology observation

Microscopic Findings histopathology observation Findings: N

Organ/Slide: Lungs; Findings: N; No microscopic findings reported.

Subject: SUBJ_23X10879 Sample: SAMP_23_3236_LUNGS Assay: ASSAY_23_3236_MICRO

SEA-CDM details

Result ID	RES_23_3236_MICRO_LUNGS
Original Assay Type	Microscopic Findings
Data Type	histopathology observation
Analysis Type	microscopic observation
Group ID	GRP_23_3236_01
Documentation ID	DOC_23_3236
Source Reference	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Related Document	IVAC pathology report 23-3236
Document Reference	IVAC pathology report: 23-3236
Clean Keys	Subject: subj_23x10879 Sample: samp_23_3236_lungs Assay: assay_23_3236_micro

histopathology observation

Microscopic Findings histopathology observation Findings: N

Organ/Slide: Salivary Glands; Findings: N; No microscopic findings reported.

Subject: SUBJ_23X10879 Sample: SAMP_23_3236_SALIVARY_GLANDS Assay: ASSAY_23_3236_MICRO

SEA-CDM details

Result ID	RES_23_3236_MICRO_SALIVARY_GLANDS
Original Assay Type	Microscopic Findings
Data Type	histopathology observation
Analysis Type	microscopic observation
Group ID	GRP_23_3236_01
Documentation ID	DOC_23_3236
Source Reference	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Related Document	IVAC pathology report 23-3236
Document Reference	IVAC pathology report: 23-3236
Clean Keys	Subject: subj_23x10879 Sample: samp_23_3236_salivary_glands Assay: assay_23_3236_micro

histopathology observation

Microscopic Findings histopathology observation Findings: N

Organ/Slide: Skeletal muscle; Findings: N; No microscopic findings reported.

Subject: SUBJ_23X10879 Sample: SAMP_23_3236_SKELETAL_MUSCLE Assay: ASSAY_23_3236_MICRO

SEA-CDM details

Result ID	RES_23_3236_MICRO_SKELETAL_MUSCLE
Original Assay Type	Microscopic Findings
Data Type	histopathology observation
Analysis Type	microscopic observation
Group ID	GRP_23_3236_01
Documentation ID	DOC_23_3236
Source Reference	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Related Document	IVAC pathology report 23-3236
Document Reference	IVAC pathology report: 23-3236
Clean Keys	Subject: subj_23x10879 Sample: samp_23_3236_skeletal_muscle Assay: assay_23_3236_micro

histopathology observation

Microscopic Findings histopathology observation Findings: N

Organ/Slide: Spleen; Findings: N; No microscopic findings reported.

Subject: SUBJ_23X10879 Sample: SAMP_23_3236_SPLEEN Assay: ASSAY_23_3236_MICRO

SEA-CDM details

Result ID	RES_23_3236_MICRO_SPLEEN
Original Assay Type	Microscopic Findings
Data Type	histopathology observation
Analysis Type	microscopic observation
Group ID	GRP_23_3236_01
Documentation ID	DOC_23_3236
Source Reference	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Related Document	IVAC pathology report 23-3236
Document Reference	IVAC pathology report: 23-3236
Clean Keys	Subject: subj_23x10879 Sample: samp_23_3236_spleen Assay: assay_23_3236_micro

histopathology observation

Microscopic Findings histopathology observation Findings: N

Organ/Slide: Sternum; Findings: N; No microscopic findings reported.

Subject: SUBJ_23X10879 Sample: SAMP_23_3236_STERNUM Assay: ASSAY_23_3236_MICRO

SEA-CDM details

Result ID	RES_23_3236_MICRO_STERNUM
Original Assay Type	Microscopic Findings
Data Type	histopathology observation
Analysis Type	microscopic observation
Group ID	GRP_23_3236_01
Documentation ID	DOC_23_3236
Source Reference	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Related Document	IVAC pathology report 23-3236
Document Reference	IVAC pathology report: 23-3236
Clean Keys	Subject: subj_23x10879 Sample: samp_23_3236_sternum Assay: assay_23_3236_micro

histopathology observation

Microscopic Findings histopathology observation Findings: N

Organ/Slide: Stomach and colon; Findings: N; No microscopic findings reported.

Subject: SUBJ_23X10879 Sample: SAMP_23_3236_STOMACH_AND_COLON Assay: ASSAY_23_3236_MICRO

SEA-CDM details

Result ID	RES_23_3236_MICRO_STOMACH_AND_COLON
Original Assay Type	Microscopic Findings
Data Type	histopathology observation
Analysis Type	microscopic observation
Group ID	GRP_23_3236_01
Documentation ID	DOC_23_3236
Source Reference	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Related Document	IVAC pathology report 23-3236
Document Reference	IVAC pathology report: 23-3236
Clean Keys	Subject: subj_23x10879 Sample: samp_23_3236_stomach_and_colon Assay: assay_23_3236_micro

Gross Lesions (12)

Special senses

Gross Lesions gross pathology observation Findings: Y Evaluated: Y

Organ/System: Special senses

Periorbital swelling around the left eye. Left eye contained liquid grey discharge at the time of necropsy.

Subject: SUBJ_23X10879 Assay: ASSAY_23_3236_GROSS

SEA-CDM details

Result ID	RES_23_3236_GROSS_SPECIAL_SENSES
Original Assay Type	Gross Lesions
Data Type	gross pathology observation
Analysis Type	gross observation
Group ID	GRP_23_3236_01
Documentation ID	DOC_23_3236
Source Reference	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Related Document	IVAC pathology report 23-3236
Document Reference	IVAC pathology report: 23-3236
Clean Keys	Subject: subj_23x10879 Assay: assay_23_3236_gross

Evaluated with no findings / routine observations (11)

Cardiovascular

Gross Lesions gross pathology observation Findings: N Evaluated: Y

Organ/System: Cardiovascular

No gross findings reported.

Subject: SUBJ_23X10879 Assay: ASSAY_23_3236_GROSS

SEA-CDM details

Result ID	RES_23_3236_GROSS_CARDIOVASCULAR
Original Assay Type	Gross Lesions
Data Type	gross pathology observation
Analysis Type	gross observation
Group ID	GRP_23_3236_01
Documentation ID	DOC_23_3236
Source Reference	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Related Document	IVAC pathology report 23-3236
Document Reference	IVAC pathology report: 23-3236
Clean Keys	Subject: subj_23x10879 Assay: assay_23_3236_gross

Endocrine

Gross Lesions gross pathology observation Findings: N Evaluated: Y

Organ/System: Endocrine

No gross findings reported.

Subject: SUBJ_23X10879 Assay: ASSAY_23_3236_GROSS

SEA-CDM details

Result ID	RES_23_3236_GROSS_ENDOCRINE
Original Assay Type	Gross Lesions
Data Type	gross pathology observation
Analysis Type	gross observation
Group ID	GRP_23_3236_01
Documentation ID	DOC_23_3236
Source Reference	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Related Document	IVAC pathology report 23-3236
Document Reference	IVAC pathology report: 23-3236
Clean Keys	Subject: subj_23x10879 Assay: assay_23_3236_gross

Gastrointestinal

Gross Lesions gross pathology observation Findings: N Evaluated: Y

Organ/System: Gastrointestinal

No gross findings reported.

Subject: SUBJ_23X10879 Assay: ASSAY_23_3236_GROSS

SEA-CDM details

Result ID	RES_23_3236_GROSS_GASTROINTESTINAL
Original Assay Type	Gross Lesions
Data Type	gross pathology observation
Analysis Type	gross observation
Group ID	GRP_23_3236_01
Documentation ID	DOC_23_3236
Source Reference	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Related Document	IVAC pathology report 23-3236
Document Reference	IVAC pathology report: 23-3236
Clean Keys	Subject: subj_23x10879 Assay: assay_23_3236_gross

Hematolymphoid

Gross Lesions gross pathology observation Findings: N Evaluated: Y

Organ/System: Hematolymphoid

No gross findings reported.

Subject: SUBJ_23X10879 Assay: ASSAY_23_3236_GROSS

SEA-CDM details

Result ID	RES_23_3236_GROSS_HEMATOLYMPHOID
Original Assay Type	Gross Lesions
Data Type	gross pathology observation
Analysis Type	gross observation
Group ID	GRP_23_3236_01
Documentation ID	DOC_23_3236
Source Reference	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Related Document	IVAC pathology report 23-3236
Document Reference	IVAC pathology report: 23-3236
Clean Keys	Subject: subj_23x10879 Assay: assay_23_3236_gross

Hepatic

Gross Lesions gross pathology observation Findings: N Evaluated: Y

Organ/System: Hepatic

No gross findings reported.

Subject: SUBJ_23X10879 Assay: ASSAY_23_3236_GROSS

SEA-CDM details

Result ID	RES_23_3236_GROSS_HEPATIC
Original Assay Type	Gross Lesions
Data Type	gross pathology observation
Analysis Type	gross observation
Group ID	GRP_23_3236_01
Documentation ID	DOC_23_3236
Source Reference	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Related Document	IVAC pathology report 23-3236
Document Reference	IVAC pathology report: 23-3236
Clean Keys	Subject: subj_23x10879 Assay: assay_23_3236_gross

Integument

Gross Lesions gross pathology observation Findings: N Evaluated: Y

Organ/System: Integument

No gross findings reported.

Subject: SUBJ_23X10879 Assay: ASSAY_23_3236_GROSS

SEA-CDM details

Result ID	RES_23_3236_GROSS_INTEGUMENT
Original Assay Type	Gross Lesions
Data Type	gross pathology observation
Analysis Type	gross observation
Group ID	GRP_23_3236_01
Documentation ID	DOC_23_3236
Source Reference	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Related Document	IVAC pathology report 23-3236
Document Reference	IVAC pathology report: 23-3236
Clean Keys	Subject: subj_23x10879 Assay: assay_23_3236_gross

Musculoskeletal

Gross Lesions gross pathology observation Findings: N Evaluated: Y

Organ/System: Musculoskeletal

No gross findings reported.

Subject: SUBJ_23X10879 Assay: ASSAY_23_3236_GROSS

SEA-CDM details

Result ID	RES_23_3236_GROSS_MUSCULOSKELETAL
Original Assay Type	Gross Lesions
Data Type	gross pathology observation
Analysis Type	gross observation
Group ID	GRP_23_3236_01
Documentation ID	DOC_23_3236
Source Reference	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Related Document	IVAC pathology report 23-3236
Document Reference	IVAC pathology report: 23-3236
Clean Keys	Subject: subj_23x10879 Assay: assay_23_3236_gross

Nervous

Gross Lesions gross pathology observation Findings: N Evaluated: N

Organ/System: Nervous

Head left intact in formalin so brain not examined.

Subject: SUBJ_23X10879 Assay: ASSAY_23_3236_GROSS

SEA-CDM details

Result ID	RES_23_3236_GROSS_NERVOUS
Original Assay Type	Gross Lesions
Data Type	gross pathology observation
Analysis Type	gross observation
Group ID	GRP_23_3236_01
Documentation ID	DOC_23_3236
Source Reference	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Related Document	IVAC pathology report 23-3236
Document Reference	IVAC pathology report: 23-3236
Clean Keys	Subject: subj_23x10879 Assay: assay_23_3236_gross

Reproductive

Gross Lesions gross pathology observation Findings: N Evaluated: Y

Organ/System: Reproductive

No gross findings reported.

Subject: SUBJ_23X10879 Assay: ASSAY_23_3236_GROSS

SEA-CDM details

Result ID	RES_23_3236_GROSS_REPRODUCTIVE
Original Assay Type	Gross Lesions
Data Type	gross pathology observation
Analysis Type	gross observation
Group ID	GRP_23_3236_01
Documentation ID	DOC_23_3236
Source Reference	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Related Document	IVAC pathology report 23-3236
Document Reference	IVAC pathology report: 23-3236
Clean Keys	Subject: subj_23x10879 Assay: assay_23_3236_gross

Respiratory

Gross Lesions gross pathology observation Findings: N Evaluated: Y

Organ/System: Respiratory

No gross findings reported.

Subject: SUBJ_23X10879 Assay: ASSAY_23_3236_GROSS

SEA-CDM details

Result ID	RES_23_3236_GROSS_RESPIRATORY
Original Assay Type	Gross Lesions
Data Type	gross pathology observation
Analysis Type	gross observation
Group ID	GRP_23_3236_01
Documentation ID	DOC_23_3236
Source Reference	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Related Document	IVAC pathology report 23-3236
Document Reference	IVAC pathology report: 23-3236
Clean Keys	Subject: subj_23x10879 Assay: assay_23_3236_gross

Urinary

Gross Lesions gross pathology observation Findings: N Evaluated: Y

Organ/System: Urinary

No gross findings reported.

Subject: SUBJ_23X10879 Assay: ASSAY_23_3236_GROSS

SEA-CDM details

Result ID	RES_23_3236_GROSS_URINARY
Original Assay Type	Gross Lesions
Data Type	gross pathology observation
Analysis Type	gross observation
Group ID	GRP_23_3236_01
Documentation ID	DOC_23_3236
Source Reference	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Related Document	IVAC pathology report 23-3236
Document Reference	IVAC pathology report: 23-3236
Clean Keys	Subject: subj_23x10879 Assay: assay_23_3236_gross

Additional Procedures (3)

Culture, left eye swab

Additional Procedures culture result

Few Streptococcus suis

Subject: SUBJ_23X10879 Sample: SAMP_23_3236_LEFT_EYE_SWAB Assay: ASSAY_23_3236_CULTURE

SEA-CDM details

Result ID	RES_23_3236_CULTURE_LEFT_EYE_SWAB
Original Assay Type	Additional Procedures
Data Type	culture result
Analysis Type	culture result
Group ID	GRP_23_3236_01
Documentation ID	DOC_23_3236
Source Reference	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Related Document	IVAC pathology report 23-3236
Document Reference	IVAC pathology report: 23-3236
Clean Keys	Subject: subj_23x10879 Sample: samp_23_3236_left_eye_swab Assay: assay_23_3236_culture

Tissues Frozen

Additional Procedures sample handling procedure

Samples of liver, kidney, and spleen held back.

Subject: SUBJ_23X10879

SEA-CDM details

Result ID	RES_23_3236_PROC_TISSUES_FROZEN
Original Assay Type	Additional Procedures
Data Type	sample handling procedure
Analysis Type	additional procedure
Group ID	GRP_23_3236_01
Documentation ID	DOC_23_3236
Source Reference	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Related Document	IVAC pathology report 23-3236
Document Reference	IVAC pathology report: 23-3236
Clean Keys	Subject: subj_23x10879

Tissues Refrigerated

Additional Procedures sample handling procedure

Swab of left eye to send for culture.

Subject: SUBJ_23X10879

SEA-CDM details

Result ID	RES_23_3236_PROC_TISSUES_REFRIGERATED
Original Assay Type	Additional Procedures
Data Type	sample handling procedure
Analysis Type	additional procedure
Group ID	GRP_23_3236_01
Documentation ID	DOC_23_3236
Source Reference	Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Related Document	IVAC pathology report 23-3236
Document Reference	IVAC pathology report: 23-3236
Clean Keys	Subject: subj_23x10879

Analysis / Final Diagnosis

SEA-CDM entity: analysis

Final pathology diagnosis

ANL_23_3236_FINAL_DIAGNOSIS | IVAC pathology report | Reference: 23-3236

Input Data

clinical history gross findings microscopic findings culture results

Interpretation / Final Diagnosis

Source

Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC

Linked SEA-CDM Records

Group: GRP_23_3236_01

Document: DOC_23_3236

SEA-CDM details

Analysis ID	ANL_23_3236_FINAL_DIAGNOSIS
Clean Analysis Key	anl_23_3236_final_diagnosis
Group ID	GRP_23_3236_01
Clean Group Key	grp_23_3236_01
Documentation ID	DOC_23_3236
Clean Documentation Key	doc_23_3236
Input Data	clinical history; gross findings; microscopic findings; culture results

Source Documents

SEA-CDM entity: documentation

1 source document record(s) are linked to this case.
Document types: necropsy pathology report (1)

IVAC pathology report 23-3236

necropsy pathology report

DOC_23_3236

Source Reference

Master 2023 Necropsy Log.xlsx::23-3236-Abdel-Latif-ACC
Source file reference only; direct public download is not available in VaxSEA.

IVAC pathology report: 23-3236

Source Study Key: STUDY_23_3236

Creator / Role

Yao Lee, DVM, MS, PhD, DACVP

ID type: name

Role: Final Review Pathologist

Case Report Metadata

Case Complete: Yes

Completion Date: 2024-01-02

Clinician: Lester/Martin

Prosector: Hasler

Gross Necropsy Pathologist: Lee

Other Contact: Suhan

SEA-CDM details

Documentation ID	DOC_23_3236
Study ID	STUDY_23_3236
Clean Study Accession	study_23_3236
Clean Documentation Key	doc_23_3236
Local Documentation ID	doc_23_3236
Raw Comments	Case Complete: Yes; Completion Date: 2024-01-02; Clinician: Lester/Martin; Prosector: Hasler; Gross necropsy pathologist: Lee; Other contact: Suhan