Iridophoroma in gecko A appeared to metastasize to multiple organs in gecko A, but such metastasis was not evident in gecko B. Moreover, histology confirmed that another main finding grossly, which was an ovarian mass or enlarged ovaries in both cases, was granulomatous oophoritis very likely due to preovulatory follicular stasis (POFS). POFS was not uncommon in captive reptiles. The cause of POFS is poorly understood (Kophamel-Orduna et al., 2018). Nutritional imbalance has been speculated as one of the causes for POFS in the literature. In our case, the animals were fed with a varied and appropriate diet, although hyporexia/anorexia may have played a role in developing the disease. In gecko B, the severe oophoritis extended to the coelom, causing coelomitis and the adherence with the distal portion of the liver. The focally extensive granulomatous hepatitis is thus believed to be an extent of oophoritis and coelomitis. No overt evidence of infectious etiology was found in the granulomatous inflammation (Gram and acid fast stains showed no bacteria). Culture of the ovarian mass from one of the geckos yielded no growth of bacteria. Gecko B also had hepatic lipidosis, which is also another common pathology in captive reptiles. Ref: Kophamel-Orduna S, Lebens M, Gunther CP, Wohlsein P, Puff C, Fehr M, et al. Lipogranulomatous Oophoritis in a Leach's giant gecko (Rhacodactylus leachianus). Wiener Tieraerztliche Monatsschrift Veterinary Medicine Austria. 2018;105(3/4 (3)):73–80.