LAM-AI Case: 23-3219-Xu-SUS

23-3219-Xu-SUS

Necropsy pathology case report for IVAC Service ID 23-3219.

LAM-AI Case ID: STUDY_23_3219

IVAC Service ID: 23-3219

Necropsy Date: 12/9/23

Species: SUS

Principal Investigator: Xu

Case Type: necropsy pathology case

Case Focus: veterinary diagnostic pathology

Reference Source: IVAC pathology report

Overview

Study

Provider: IVAC pathology report
Case Information: STUDY_23_3219 — necropsy pathology case
Goal: veterinary diagnostic pathology
Title: 23-3219-Xu-SUS

Subject

2 animals Species: SUS ID: SUBJ_23_3219_ANIMAL_2, SUBJ_23X10872

Presented 12/9 for concerns of respiratory distress with previous history of general anesthesia involving craniotomy and intubation. Euthanized given decline in respiratory status.

Samples

6 tissue/sample records 2 handling/retention records

Heart, Kidneys, Larynx, Liver, Lungs, Spleen

Sample records link to corresponding gross and microscopic findings where a reliable relationship is available.

Assays / Findings

Report

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Final Diagnosis / Conclusion

Final Diagnoses

Organ/System	Process	Diagnosis
Respiratory	Trauma	Laryngeal trauma with perforation and subsequent pneumomediastinum/retroperitoneum
Respiratory	Inflammatory	Necrotizing and suppurative laryngitis with intralesional bacteria

Final Comments / Conclusion

Gross and histological findings are consistent with trauma to the larynx at the level of the median ventral and lateral ventricles, just caudal to the vocal folds. These blind ended pouches, along with sharp angle of deflection from the pharynx through the larynx to the trachea, and the naturally narrow diameter of the larynx can commonly make intubation in pigs difficult. No other significant lesions were noted histologically. Bacterial culture grew common commensal organisms, but not primary pathogens.

Clinical History

Clinical History Narrative

Presented 12/9 for concerns of respiratory distress with previous history of general anesthesia involving craniotomy and intubation. Euthanized given decline in respiratory status.

Animal / Subject Profile (2)

Animal ID	Clinical Number	Species	Age	Sex	Genotype / Strain	Mode of Death
SUBJ_23_3219_ANIMAL_2		SUS	N/A	Not specified	N/A	Ben Curtis
15-14	23x10872	SUS	~30 kg	M	SUS	Euthanized-Injectable

Interventions / Treatments

No intervention or treatment records are linked to this case.

Recorded Conditions / Events (6)

Condition / Event	Severity	Timing	Subject	Details
Tracheitis, laryngitis,	marked	necropsy date	SUBJ_23_3219_ANIMAL_2	Organ/System: Larynx; Process: Trauma; Morphologic Diagnosis: Tracheitis, laryngitis, with fibrinonecrotic membrane, marked, acute
Laryngeal trauma	Not specified	necropsy date	SUBJ_23_3219_ANIMAL_2	Organ/System: Respiratory; Process: Trauma; Diagnosis: Laryngeal trauma with perforation and subsequent pneumomediastinum/retroperitoneum
Necrotizing and suppurative laryngitis	Not specified	necropsy date	SUBJ_23_3219_ANIMAL_2	Organ/System: Respiratory; Process: Inflammatory; Diagnosis: Necrotizing and suppurative laryngitis with intralesional bacteria
Tracheitis, laryngitis,	marked	necropsy date	SUBJ_23X10872	Organ/System: Larynx; Process: Trauma; Morphologic Diagnosis: Tracheitis, laryngitis, with fibrinonecrotic membrane, marked, acute
Laryngeal trauma	Not specified	necropsy date	SUBJ_23X10872	Organ/System: Respiratory; Process: Trauma; Diagnosis: Laryngeal trauma with perforation and subsequent pneumomediastinum/retroperitoneum
Necrotizing and suppurative laryngitis	Not specified	necropsy date	SUBJ_23X10872	Organ/System: Respiratory; Process: Inflammatory; Diagnosis: Necrotizing and suppurative laryngitis with intralesional bacteria

Final diagnoses and microscopic morphologic diagnoses are summarized separately at the bottom of Overview and in the pathology findings tabs.

Samples

Tissues / Samples (6)

Tissue / Organ	Sample Type	Collection	Subject
Heart SAMP_23_3219_HEART	histology slide/tissue	necropsy 2023-12-09 T0: necropsy date	N/A
Kidneys SAMP_23_3219_KIDNEYS	histology slide/tissue	necropsy 2023-12-09 T0: necropsy date	N/A
Larynx SAMP_23_3219_LARYNX	histology slide/tissue	necropsy 2023-12-09 T0: necropsy date	N/A
Liver SAMP_23_3219_LIVER	histology slide/tissue	necropsy 2023-12-09 T0: necropsy date	N/A
Lungs SAMP_23_3219_LUNGS	histology slide/tissue	necropsy 2023-12-09 T0: necropsy date	N/A
Spleen SAMP_23_3219_SPLEEN	histology slide/tissue	necropsy 2023-12-09 T0: necropsy date	N/A

Microscopic and additional-assay links use direct sample relationships. Gross links use a controlled tissue-to-organ-system mapping and are only shown when a confident mapping is available.

Frozen / Refrigerated / Retained Materials (2)

Tissues Frozen

lung, liver, kidney, spleen, GI (cecum, small intestine, large intestine)

Tissues Refrigerated

Culture swabs from the ventral tracheal abscess and pericardial abscess were saved.

Gross Findings

Finding present Evaluated, no finding Not evaluated / unavailable

Organ System	Evaluated? (Y/N/Some animals)	Findings Y/N	Comments
Cardiovascular	Y	Y	Marked diffuse mediastinal emphysema which extends caudally through the diaphragm to the retroperitoneal space. A small pericardial abscess adhered to cardiac apex (swabbed).
Endocrine	Y	N
Gastrointestinal	Y	N	food noted in stomach
Hematolymphoid	Y	N
Hepatic	Y	N
Integument	Y	Y	Focal erosion at plenum of nose. Craniotomy surgery site is intact, clean, and free of exudate. Deep to the incision is a large hematoma.
Musculoskeletal	Y	N
Nervous	Y	N	The meninges deep to the hematoma are intact, clean, and free of exudate. The brain tissue is unremarkable.
Reproductive	Y	N
Respiratory	Y	Y	Lungs float in formalin, blood clots noted in large airways with caudal lobe edema. Trachea adjacent to larynx demonstrated multifocal to coalescing dark-green discoloration with fibrinonecrotic membrane. Thyroid membrane/ligament of larynx thinned but intact with potential compromise. Just caudal to the vocal folds, at the edges of the ventral median and lateral ventricles are markedly hemorrhagic, hyperemic, and lined by necrotic debris (swabbed - submitted). The injury tracks deeper ventrally into the surrounding soft tissues and opens into a pocket of purulent exudate (swabbed). Tissues around the larynx are emphysematous. The mucosal surface of the trachea distally is smooth, shiny, and clean.
Urinary	Y	Y	Retroperitoneal emphysema is most easily observed by the left kidney.

Microscopic Findings

Finding present Examined, no finding Not evaluated / unavailable

Organ / Slide	Findings Y/N	Description
Heart	N; NO MICROSCOPIC FINDINGS REPORTED.
Kidneys	N; NO MICROSCOPIC FINDINGS REPORTED.
Larynx	Y	Regionally extensive mucosal ulceration, necrosis with marked suppurative inflammation and colonizing bacterial colonies.
Liver	N; NO MICROSCOPIC FINDINGS REPORTED.
Lungs	Y	Mild to moderate expansion of the alveolar septae. Alveolar spaces are generally unremarkable.
Spleen	N; NO MICROSCOPIC FINDINGS REPORTED.

Microscopic Morphologic Diagnoses

Organ / System	Process	Morphologic Diagnosis
Larynx	Trauma	Tracheitis, laryngitis, with fibrinonecrotic membrane, marked, acute

Additional Assays

Procedures / Results (1)

Procedure	Sample / Tissue	Result	Subject	Source
Other sample handling procedure	N/A	The swab from the larynx, injury site, was sent for general bacteria culture	N/A	IVAC pathology report 23-3219

Documentation

Document	Type	Provider / Creator	File / Reference	Status
IVAC pathology report 23-3219	necropsy pathology report	Benjamin Curtis, DVM, DACVP Final Review Pathologist	Master 2023 Necropsy Log.xlsx::23-3219-Xu-SUS Source file reference only; direct public download is not available in VaxSEA. IVAC pathology report: 23-3219	Complete: Yes 2023-12-19

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